- Network: ESPN+ PPV
- Venue: Madison Square Garden
- Location: New York, New York
- Event Date: November 6, 2021 1:00PM
Main Card (Pay-Per-View (10:00 p.m. ET/7:00 p.m. ET)
Kamaru Usman (C) vs. (#1) Colby Covington — UFC Welterweight Championship
Rose Namajunas (C) vs. (#1) Zhang Weili — UFC Women's Strawweight Championship
(#2) Justin Gaethje vs. (#4) Michael Chandler
(#14) Shane Burgos vs. Billy Quarantillo
(#8) Frankie Edgar vs. (#13) Marlon Vera
Prelims (ESPN+, 8:00 p.m. ET/5:00 p.m. PT)
Alex Pereira vs. Andreas Michailidis
Al Iaquinta vs. Bobby Green
Edmen Shahbazyan vs. Nassourdine Imavov
Phil Hawes vs. Chris Curtis
Early Prelims (6:00 p.m. ET/3:00 p.m. PT)
Ian Garry vs. Jordan Williams
Gian Villante vs. Chris Barnett
Aleksa Camur vs. John Allan
Melsik Baghdasaryan vs. TJ Laramie
CJ Vergara vs. Ode Osbourne
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