- Prior to UFC 241, Stipe Miocic hadn't fought in over a year, Nate Diaz hadn't fought in nearly three years, and both Yoel Romero Paulo Costa hadn't fought in over a year. Four of the top six fighters on UFC 241 are facing layoffs of over a year.
- The first six fights of the night all went to a decision. Only one of those had a round scored 10-8, which was the night's opener between Mazo and Dobson.
- There were nine ranked fighters on UFC 241. Nate Diaz was ranked before being removed due to inactivity.
- Nate Diaz hasn't fought at lightweight since 2015. 16 of his fights in the UFC have been at lightweight, seven at welterweight, and one at 160 pound catchweight after missing weight.
- Stipe Miocic has now beaten four men who have been UFC Champions.
- Daniel Cormier's first heavyweight loss ever came at UFC 241.
- Yoel Romero now has lost three of four, with all of those losses coming via decision. He doesn't have a win over someone currently in the middleweight division since 2015.
- Anthony Pettis hasn't won back-to-back fights since he was UFC Lightweight Champion in 2013 and 2014.
- Before his last two wins, Nate Diaz had never beaten a former or eventual UFC Champion.
